Selected Publications by Topic

Macrophage Function and Inflammation after Spinal Cord Injury

Cerqueira SR, Benavides S, Lee HE, Ayad NG, Lee JK. (2022) BET protein inhibition promotes non-myeloid cell mediated neuroprotection after rodent spinal cord contusion. Experimental Neurololgy. 352:114035.

Ryan, C.B., Choi, J.S., Al-Ali, H., Lee, J.K. (2022) Myelin and non-myelin debris contribute to foamy macrophage formation after spinal cord injury. Neurobiology of Disease. 163:105608

Cerqueira, S.R., Ayad, N., Lee, J.K. (2020) Neuroinflammation treatment via targeted delivery of nanoparticles. Frontiers in Cellular Neuroscience. 14:576037.

Yang, L.*, Conley, B.M.*, Cerqueira, S.R.*, Pongkulapa, T., Wang, S., Lee, J.K.#, Lee, K.B.# (2020) Effective modulation of CNS inhibitory microenvironment using bio-inspired hybrid nanoscaffold-based therapeutic interventions. Advanced Materials. 32(43):e2002578. *equal contribution, #co-corresponding

Milich, L.M.*, Ryan, C.B.*, Lee, J.K. (2019) The origin, fate, and contribution of macrophages to spinal cord injury pathology. Acta Neuropathologica. 137(5):799-800. *equal contribution

Rudman, M.D., Choi, J.S., Lee, H.E., Tan, S.K., Ayad, N.G., Lee, J.K. (2018) Bromodomain and extraterminal domain-containing protein inhibition attenuates acute inflammation after spinal cord injury. Experimental Neurology. 309:181-192.

Zhu, Y.*, Lyapichev, K.*, Lee, D.H., Motti, D., Ferraro, N.M., Zhang, Y., Yahn, S., Soderblom, C., Zha, J., Bethea, J.R., Spiller, K.L., Lemmon, V.P., Lee, J.K. (2017) Macrophage transcriptional profile identifies lipid catabolic pathways that can be therapeutically targeted after spinal cord injury. Journal of Neuroscience. 37(9):2362-2376. *equal contribution

Zhu, Y., Soderblom, C., Krishnan, V., Ashbaugh, J., Bethea, J.R., Lee, J.K. (2015) Hematogenous macrophage depletion reduces the fibrotic scar and increases axonal growth after spinal cord injury. Neurobiology of Disease. 74:114-25.

Mechanisms of Fibrotic Scar Formation after CNS Injury

Fehlberg, C.R., Lee. J.K. (2021) Fibrosis in the central nervous system: from the meninges to the vasculature. Cell and Tissue Research. Online.

Milich, L.M.*, Choi, J.S.*, Ryan, C.B., Cerqueira, S.R., Benavides, S., Yahn, S.L., Tsoulfas, P., Lee, J.K. (2021) Single cell analysis of the cellular heterogeneity and interactions in the injured mouse spinal cord. Journal of Experimental Medicine. 218(8):e20210040. *equal contribution

Yahn, S.L., Li, J., Goo, I., Gao, H., Brambilla, R., Lee, J.K. (2019) Fibrotic scar after experimental autoimmune encephalomyelitis inhibits oligodendrocyte differentiation. Neurobiology of Disease. 134:104674.

Hong, L., Kim, Y.M., Park, H.H., Hwang, D.H., Cui, Y., Lee, E.M., Yahn, S., Lee, J.K., Song, S.C., Kim, B.G. (2017) An injectable hydrogel enhances tissue repair after spinal cord injury by promoting extracellular matrix remodeling. Nature Communications. 8(1):533

Funk, L.H., Hackett, A.R., Bunge, M.B., Lee, J.K. (2016) Tumor necrosis factor superfamily member APRIL contributes to fibrotic scar formation after spinal cord injury. Journal of Neuroinflammation. 13(1):87.

Zhu, Y., Soderblom, C., Trojanowsky, M., Lee, D.H., Lee, J.K. (2015) Fibronectin matrix assembly after spinal cord injury. Journal of Neurotrauma. 32(15):1158-67. Cover illustration

Zhu, Y., Soderblom, C., Krishnan, V., Ashbaugh, J., Bethea, J.R., Lee, J.K. (2015) Hematogenous macrophage depletion reduces the fibrotic scar and increases axonal growth after spinal cord injury. Neurobiology of Disease. 74:114-25.

Soderblom, C., Luo, X., Blumenthal, E., Bray, E., Lyapichev, K., Ramos, J., Krishnan, V., Lai-Hsu, C., Park, K.K., Tsoulfas, P., Lee, J.K. (2013) Perivascular fibroblasts form the fibrotic scar after contusive spinal cord injury. Journal of Neuroscience. 33(34):13882-887.

Oligodendrocyte Progenitor Response after CNS Injury

Hackett, A.R.*, Yahn, S.L.*, Lyapichev, K., Dajnoki, A., Lee, D.H., Rodriguez, M., Cammer, N., Pak, J., Mehta, S.T., Bodamer, O., Lemmon, V.P., Lee, J.K. (2018) Injury type-dependent differentiation of NG2 glia into heterogeneous astrocytes. Experimental Neurology. 308:72-79. *equal contribution

Hackett A., Lee JK. (2016) Understanding the NG2 glial scar. Frontiers in Neurology.15;7:199

Hackett A.R.*, Lee D.H.*, Dawood A., Rodriguez M., Funk L., Tsoulfas P., Lee J.K. (2016) STAT3 and SOCS3 regulate NG2 cell proliferation and differentiation after contusive spinal cord injury. Neurobiology of Disease. 22;89:10-22. Cover illustration. *equal contribution

Other Notable Publications

Penas C., Maloof M.E., Stathias V., Long J., Tan S.K., Mier J., Fang Y., Valdes C., Rodriguez-Blanco J., Chiang C.M., Robbins D.J., Liebl D.J., Lee J.K., Hatten M.E., Clarke J., Ayad N.G. (2019) Time series modeling of cell cycle exit identifies Brd4 dependent regulation of cerebellar neurogenesis. Nature Communications. 10(1):3028

Petersen M.A., Ryu J.K., Chang K.J., Etxeberria A., Bardehle S., Mendiola A.S., Kamau-Devers W., Fancy S.P.J., Thor A., Bushong E.A., Baeza-Raja B., Syme C.A., Wu M.D., Rios Coronado P.E., Meyer-Franke A., Yahn S., Pous L., Lee J.K., Schachtrup C., Lassmann H., Huang E.J., Han M.H., Absinta M., Reich D.S., Ellisman M.H., Rowitch D.H., Chan J.R., Akassoglou K. (2017) Fibrinogen Activates BMP Signaling in Oligodendrocyte Progenitor Cells and Inhibits Remyelination after Vascular Damage. Neuron. 96(5):1003-1012

Luo X, Ribeiro M, Bray E.R., Lee D.H., Yungher B.J., Mehta S.T., Thakor K.A., Diaz F., Lee J.K., Moraes C.T., Bixby J.L., Lemmon V.P., Park K.K. (2016) Enhanced transcriptional activity and mitochondrial localization of STAT3 co-induce axon regrowth in the adult central nervous system. Cell Reports. 15(2):398-410.

Al-Ali, H., Lee, D.H., Danzi, M.C., Nassif, H., Gautam, P., Wennerberg, K., Zuercher, B., Drewry, D.H., Lee, J.K., Lemmon, V.P., Bixby, J.L.(2015) Rational polypharmacology: systematically identifying and engaging multiple drug targets to promote axon growth. ACS Chemical Biology. 10(8):1939-51. Cover illustration

Lorenzana, A.O., Lee, J.K., Mui, M., Chang, A., Zheng, B. (2015) A surviving intact branch stabilizes remaining axon architecture after injury as revealed by in vivo imaging in the mouse spinal cord. Neuron. 86(4):947-54

Soderblom, C., Lee, D.H., Dawood, A., Carballosa, M., Santamaria, A.J., Benavides, F.D., Jergova, S., Grumbles, R.M., Thomas, C.K., Park, K.K., Guest, J.D., Lemmon, V.P., Lee, J.K.*, Tsoulfas, P.* (2015) 3D imaging of transparent spinal cords from rodents and nonhuman primates. eNeuro. 2(2):1-24. *Co-corresponding authors

Lee, D.H., Luo, X., Yungher, B., Bray, E., Lee, J.K.*, Park, K.K.* (2014) mTOR's distinct roles and effectiveness in promoting compensatory axonal sprouting in the injured CNS. Journal of Neuroscience. 34(46):15347-55. *Co-corresponding authors

Blackmore, M.G., Wang, Z., Lerch J., Motti, D., Zhang, Y.P., Shields, C., Lee, J.K., Goldberg, J.L., Lemmon, V.P., Bixby, J.L. (2012) KLF7 engineered for transcriptional activation promotes axon regeneration in the adult corticospinal tract. Proceedings National Academy Science. 109(19):7517-22. PMID: 22529377

Liu, K., Lu, Y., Lee, J.K., Samara, R, Willenberg, R., Sears-Kraxberger, I., Tedeschi, A., Park, K., Cai, B., Xu, B., Steward, O., Zheng, B., and He, Z. (2010) PTEN deletion enhances the regenerative ability of adult corticospinal neurons. Nature Neuroscience. 13(9):1075-81. Cover illustration

Lee, J.K., Geoffroy, C.G., Chan, A.F., Tolentino, K.E., Crawford, M.J., Leal, M.A., Kang, B., and Zheng, B. (2010) Assessing spinal axon regeneration and sprouting in Nogo, MAG and OMgp deficient mice. Neuron. 66(5):663-70. Previewed article. PMCID: PMC2896331

Davalos, D.*, Lee, J.K.*, Brinkman, B., Zheng, B., Akassoglou, K. (2008) Stable in vivo imaging of densely populated glia, axons and blood vessels in the mouse spinal cord using two-photon microscopy. Journal of Neuroscience Methods. 169(1):1-7. *equal contribution. Cover illustration

Schachtrup, C., Lu, P., Jones, L., Lee, J.K., Sachs, B.D., Lu, J, Zheng, B., and Akassoglou, K. (2007) Fibrinogen inhibits neurite outgrowth via beta3 integrin-mediated phosphorylation of the EGF receptor. Proceedings National Academy Science. 104(28):11814-9. PMCID: PMC1913857